Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | F12 | P00748 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL434503 | 0.81 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL15241829 | 0.79 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL12528294 | 0.76 | KDM4E (1.00) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL18622990 | 0.72 | ALDH1A1 (0.76) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL18622974 | 0.71 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL16660102 | 0.71 | MAPT (0.58) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL12528203 | 0.71 | KDM4E (0.66) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL18622977 | 0.70 | KDM4E (0.72) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL13870737 | 0.68 | TDP1 (0.61) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL18622983 | 0.68 | KDM4E (0.64) | ALDH1A1KDM4EHPGDMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644371-A1 | PYRAZOLOISOQUINOLINE DERIVATIVES AS KINASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005012301-A1 | PYRAZOLOISOQUINOLINE DERIVATIVES AS KINASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-02-10 | — | — | WO | disclosed |