Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 2/20 | 0.81 |
| ▸ | ESRRG | P62508 | 13/20 | 0.74 |
| ▸ | ESR1 | P03372 | 12/20 | 0.74 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | PGR | P06401 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ESRRA | P11474 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | GBA1 | P04062 | 1/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5738252 | 1.00 | HTR6 (0.81) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5738255 | 1.00 | HTR6 (0.81) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5739474 | 0.95 | HTR6 (0.91) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5737155 | 0.95 | HTR6 (0.91) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5738332 | 0.95 | HTR6 (0.74) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5736463 | 0.95 | HTR6 (0.91) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5736471 | 0.95 | HTR6 (0.91) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5738558 | 0.95 | HTR6 (0.74) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5738338 | 0.95 | HTR6 (0.74) | HTR6LMNAESRRGESR1ESR2 | |
| SCHEMBL5739418 | 0.95 | HTR6 (0.91) | HTR6LMNAESRRGESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1705169-A2 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | Hormos Medical Ltd. (FI) | 2006-09-27 | — | — | EP | disclosed |
| US-6576645-B1 | Such as 3-(4-chloro-1-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl)--2-phenylbut-1 -enyl)phenol; producing tissue specific estro-genic and/or antiestrogenic effect | HORMOS MEDICAL OY LTD (FI) | 2003-06-10 | — | — | US | disclosed |