Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 6/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739305 | 0.92 | NR1H4 (0.46) | ESRRGGCGRSPHK2SPHK1EPHX2 | |
| SCHEMBL5737439 | 0.90 | ESRRG (0.40) | ESRRGGCGRSPHK2SPHK1ALDH1A1 | |
| SCHEMBL5738615 | 0.90 | ESRRG (0.40) | ESRRGGCGRSPHK2SPHK1EPHX2 | |
| SCHEMBL5738665 | 0.89 | CA1 (0.43) | ESRRGGCGRSPHK2SPHK1ALDH1A1 | |
| SCHEMBL5738808 | 0.83 | ESRRG (0.41) | ESRRGGCGRSPHK2SPHK1EPHX2 | |
| SCHEMBL5739422 | 0.83 | ESRRG (0.43) | ESRRGGCGRSPHK2SPHK1EPHX2 | |
| SCHEMBL5738274 | 0.82 | PHGDH (0.40) | SPHK2SPHK1ALDH1A1MAPTHTT | |
| SCHEMBL5738456 | 0.82 | SPHK2 (0.34) | ESRRGGCGRSPHK2SPHK1ALDH1A1 | |
| SCHEMBL1484328 | 0.81 | ESRRG (0.44) | ESRRGGCGREPHX2NR1H4ALDH1A1 | |
| SCHEMBL13720945 | 0.81 | ESRRG (0.44) | ESRRGGCGREPHX2NR1H4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636192-A1 | 3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS | Nissan Chemical Industries, Ltd. (JP) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004108683-A1 | 3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2004-12-16 | — | — | WO | disclosed |