Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | GSR | P00390 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673738 | 0.90 | GABRR1 (0.33) | MEN1GAAKMT2ACA14HDAC1 | |
| SCHEMBL13215105 | 0.87 | HDAC6 (0.36) | MEN1GAAKMT2ACA14HDAC1 | |
| SCHEMBL2396942 | 0.86 | CTSK (0.35) | MEN1GAAKMT2ACA14HDAC1 | |
| SCHEMBL2396945 | 0.86 | CTSK (0.35) | MEN1GAAKMT2ACA14HDAC1 | |
| SCHEMBL27612964 | 0.85 | CA14 (0.34) | CA14HDAC1HDAC2HDAC6AAK1 | |
| SCHEMBL3838124 | 0.85 | CA14 (0.34) | CA14HDAC1HDAC2HDAC6AAK1 | |
| SCHEMBL25185999 | 0.82 | CA14 (0.38) | MEN1GAAKMT2ACA14HDAC1 | |
| SCHEMBL12808019 | 0.82 | CA14 (0.38) | MEN1GAAKMT2ACA14HDAC1 | |
| SCHEMBL30955849 | 0.80 | CA14 (0.32) | CA14HDAC1HDAC2HDAC6AAK1 | |
| SCHEMBL32661810 | 0.79 | MEN1 (0.31) | MEN1GAAKMT2ACA14HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1624874-A4 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2006-11-22 | — | — | EP | disclosed |
| EP-1624874-A2 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck & Co., Inc. (US) | 2006-02-15 | — | — | EP | disclosed |
| WO-2004103276-A2 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2004-12-02 | — | — | WO | disclosed |