Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740887 | 0.88 | EGFR (0.50) | EGFRERBB2KDRMAP2K1MAPK14 | |
| SCHEMBL5740274 | 0.87 | EGFR (0.56) | EGFRERBB2KDRMAP2K1MAPK14 | |
| SCHEMBL5739277 | 0.86 | EGFR (0.58) | EGFRERBB2KDRMAP2K1MAPK14 | |
| SCHEMBL5740085 | 0.85 | EGFR (0.62) | EGFRERBB2KDRMAP2K1MAPK14 | |
| SCHEMBL4046184 | 0.85 | EGFR (0.73) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL5741555 | 0.85 | EGFR (0.59) | EGFRERBB2KDRMAP2K1MAPK14 | |
| SCHEMBL5740201 | 0.85 | EGFR (0.75) | EGFRERBB2KDR | |
| SCHEMBL5740197 | 0.83 | KDR (0.66) | EGFRERBB2KDRMAPK14 | |
| SCHEMBL5739459 | 0.83 | EGFR (0.74) | EGFRERBB2KDRMAP2K1MAPK14 | |
| SCHEMBL5740337 | 0.83 | KDR (0.54) | EGFRERBB2KDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |