Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.75 |
| ▸ | KDR | P35968 | 8/20 | 0.53 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741536 | 0.90 | EGFR (0.64) | EGFRERBB2KDR | |
| SCHEMBL4052320 | 0.86 | EGFR (1.00) | EGFRERBB2KDR | |
| SCHEMBL5739484 | 0.85 | EGFR (0.54) | EGFRERBB2KDR | |
| SCHEMBL5740197 | 0.85 | KDR (0.66) | EGFRERBB2KDR | |
| SCHEMBL5740274 | 0.84 | EGFR (0.56) | EGFRERBB2KDR | |
| SCHEMBL5740337 | 0.84 | KDR (0.54) | EGFRERBB2KDR | |
| SCHEMBL5739277 | 0.83 | EGFR (0.58) | EGFRERBB2KDR | |
| SCHEMBL5740085 | 0.83 | EGFR (0.62) | EGFRERBB2KDR | |
| SCHEMBL5741555 | 0.83 | EGFR (0.59) | EGFRERBB2KDR | |
| SCHEMBL5738803 | 0.83 | EGFR (0.60) | EGFRERBB2KDRFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |