Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 4/20 | 0.34 |
| ▸ | TDO2 | P48775 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14451971 | 0.93 | ALDH1A1 (0.35) | MAPTALDH1A1L3MBTL1GAAIDO1 | |
| SCHEMBL5740055 | 0.91 | MAPT (0.35) | MAPTALDH1A1L3MBTL1GAAIDO1 | |
| SCHEMBL4047213 | 0.89 | PDE4A (0.41) | MAPTALDH1A1L3MBTL1GAAIDO1 | |
| SCHEMBL14452013 | 0.86 | POLB (0.41) | MAPTL3MBTL1IDO1TDO2POLB | |
| SCHEMBL1462071 | 0.85 | MAPK14 (0.38) | MAPTALDH1A1L3MBTL1IDO1TDO2 | |
| SCHEMBL1459917 | 0.83 | MAPK14 (0.39) | MAPTALDH1A1L3MBTL1GAAIDO1 | |
| SCHEMBL4048478 | 0.83 | KDR (0.47) | MAP2K1 | |
| SCHEMBL4052257 | 0.83 | IDO1 (0.34) | MAPTALDH1A1L3MBTL1GAAIDO1 | |
| SCHEMBL5740098 | 0.82 | ALDH1A1 (0.41) | MAPTALDH1A1L3MBTL1GAAPOLB | |
| SCHEMBL5739045 | 0.81 | ALDH1A1 (0.41) | MAPTALDH1A1L3MBTL1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |