Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.58 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740841 | 0.85 | MEN1 (0.43) | KDRMAPK14 | |
| SCHEMBL4047619 | 0.83 | KDR (0.59) | KDRMAPK14MAP2K1 | |
| SCHEMBL4048067 | 0.83 | KDR (0.69) | KDRMAPK14MAP2K1 | |
| SCHEMBL4047004 | 0.77 | MAPK14 (0.61) | KDRMAPK14MAP2K1 | |
| SCHEMBL4045485 | 0.76 | KDR (1.00) | KDRMAPK14MAP2K1 | |
| SCHEMBL4044574 | 0.74 | KDR (0.58) | KDRMAPK14MAP2K1 | |
| SCHEMBL7251768 | 0.74 | KDR (0.78) | KDRMAPK14MAP2K1 | |
| SCHEMBL4053778 | 0.74 | KDR (0.78) | KDRMAPK14MAP2K1 | |
| SCHEMBL4050078 | 0.74 | KDR (0.72) | KDRMAPK14MAP2K1 | |
| SCHEMBL4045268 | 0.74 | KDR (0.71) | KDRMAPK14MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |
| US-6982265-B1 | Pyrrolotriazine inhibitors of kinases | BRISTOL MYERS SQUIBB COMPANY (US) | 2006-01-03 | — | — | US | claimed |