Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740291 | 0.85 | KDR (0.61) | KDRMAPK14 | |
| SCHEMBL5738800 | 0.83 | KDR (0.48) | KDRMAPK14 | |
| SCHEMBL5741657 | 0.78 | MAPK14 (0.44) | KDRMAPK14 | |
| SCHEMBL5739893 | 0.77 | KDR (0.71) | KDRMAPK14 | |
| SCHEMBL5740703 | 0.76 | ADORA1 (0.41) | MEN1KMT2AKDRMAPK14SMN1; SMN2 | |
| SCHEMBL5739937 | 0.75 | KDR (0.56) | MEN1KMT2AKDRMAPK14SMN1; SMN2 | |
| SCHEMBL5740473 | 0.75 | MAP2K1 (0.52) | KDRMAPK14 | |
| SCHEMBL5739102 | 0.75 | KDR (0.51) | KDR | |
| SCHEMBL5740633 | 0.74 | MAPK14 (0.52) | MAPK14 | |
| SCHEMBL5740297 | 0.74 | KDR (0.46) | KDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |