Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | KIF5B | P33176 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049767 | 0.84 | KDR (0.62) | KDRMAPK14 | |
| SCHEMBL5740699 | 0.84 | EGFR (0.46) | KDREGFRRETKIF5BMAPK14 | |
| SCHEMBL5740097 | 0.80 | KDR (0.56) | KDREGFRMAPK14 | |
| SCHEMBL1459959 | 0.79 | KDR (0.46) | KDREGFRRETKIF5BMAPK14 | |
| SCHEMBL5738803 | 0.79 | EGFR (0.60) | KDREGFR | |
| SCHEMBL5740556 | 0.78 | KDR (0.62) | KDREGFRMAPK14 | |
| SCHEMBL5738800 | 0.78 | KDR (0.48) | KDREGFRRETKIF5BMAPK14 | |
| SCHEMBL5741836 | 0.78 | KDR (0.72) | KDREGFR | |
| SCHEMBL5740633 | 0.77 | MAPK14 (0.52) | MAPK14 | |
| SCHEMBL5740103 | 0.77 | KDR (0.59) | KDREGFRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |