Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3952711 | 0.80 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1KDM4ELMNAHTT | |
| SCHEMBL6218407 | 0.79 | MAPT (0.60) | ALDH1A1L3MBTL1KDM4ELMNAHTT | |
| SCHEMBL5741385 | 0.77 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1KDM4ELMNAHTT | |
| SCHEMBL1572805 | 0.76 | MAPT (0.47) | ALDH1A1L3MBTL1LMNAHTTMAPT | |
| SCHEMBL2313100 | 0.75 | MAPT (0.45) | ALDH1A1KDM4ELMNAMAPTHSD17B10 | |
| SCHEMBL2519397 | 0.75 | NPC1 (0.46) | ALDH1A1L3MBTL1KDM4ELMNAHTT | |
| SCHEMBL321447 | 0.75 | MAPT (0.58) | ALDH1A1L3MBTL1KDM4ELMNAHTT | |
| SCHEMBL2515131 | 0.73 | ALDH1A1 (0.45) | ALDH1A1KDM4ELMNAHTTMAPT | |
| SCHEMBL6653355 | 0.72 | MAPK14 (0.54) | ALDH1A1L3MBTL1LMNAHTTTUBB4A | |
| SCHEMBL321257 | 0.72 | MAPT (0.43) | ALDH1A1KDM4ELMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664047-A1 | SUBSTITUTED INDOLIZINE 1,2,3,6,7,8 DERIVATIVES, FGFS INHIBITORS, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | Sanofi-Aventis (FR) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005028476-A1 | SUBSTITUTED INDOLIZINE 1,2,3,6,7,8 DERIVATIVES, FGFS INHIBITORS, A METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI-AVENTIS (FR) | 2005-03-31 | — | — | WO | disclosed |