Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2898193 | 0.84 | KCNH2 (0.53) | DRD4KDM4EDRD2ALDH1A1KCNH2 | |
| SCHEMBL27648714 | 0.84 | HTR1A (0.46) | KDM4EHTR1AHTR7ALDH1A1 | |
| SCHEMBL3107655 | 0.81 | GRM5 (0.47) | GAALMNAALDH1A1 | |
| SCHEMBL2895891 | 0.77 | NOTUM (0.54) | GAALMNAALDH1A1 | |
| SCHEMBL2895023 | 0.76 | GRM5 (0.44) | GAALMNAALDH1A1 | |
| SCHEMBL2897512 | 0.74 | DPP4 (0.49) | KDM4ELMNAALDH1A1KCNH2 | |
| SCHEMBL5739242 | 0.74 | MAPK1 (0.48) | DRD4KDM4EOPRM1SIGMAR1LMNA | |
| SCHEMBL10294634 | 0.73 | KCNH2 (0.69) | SIGMAR1KCNH2 | |
| SCHEMBL5739257 | 0.73 | GRM5 (0.42) | GAALMNAALDH1A1 | |
| SCHEMBL3955492 | 0.73 | GRM5 (0.42) | GAALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | claimed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | claimed |