Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2889477 | 0.88 | HPGD (0.36) | HPGDMPOFAAHMGLLABCG2 | |
| SCHEMBL5741959 | 0.87 | PKM (0.38) | HPGDALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL5739060 | 0.87 | MAPT (0.43) | HPGDALDH1A1LMNAMAPT | |
| SCHEMBL5739267 | 0.83 | HPGD (0.34) | HPGDMPO | |
| SCHEMBL5739576 | 0.83 | GRM5 (0.45) | ALDH1A1MAPTHTT | |
| SCHEMBL2910592 | 0.77 | HPGD (0.40) | HPGDMPOFAAHMGLLABCG2 | |
| SCHEMBL2896574 | 0.75 | HPGD (0.43) | HPGDMPOFAAHMGLLABCG2 | |
| SCHEMBL2895781 | 0.74 | PKM (0.39) | HPGDMPOALDH1A1LMNAMAPT | |
| SCHEMBL2897428 | 0.74 | MAPT (0.45) | HPGDALDH1A1LMNAMAPT | |
| SCHEMBL2894710 | 0.72 | GRM5 (0.39) | HPGDMPOFAAHMGLLS1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |