SCHEMBL5740541

SCHEMBL5740541

C1CCC(NC2CCCCC2)CC1.C=CCCCCCC(NC(=O)OC1CCCC1)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 2/20 0.54
HDAC1 Q13547 2/20 0.54
EPHX1 P07099 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CPB2 Q96IY4 6/20 0.38
HDAC6 Q9UBN7 1/20 0.38
EPHX2 P34913 2/20 0.34
LMNA P02545 1/20 0.34
CASP1 P29466 1/20 0.34
TGM2 P21980 1/20 0.33
ITGB3 P05106 1/20 0.33
ITGAV P06756 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2812234 0.93 HDAC4 (0.51) HDAC4HDAC1EPHX1SMN1; SMN2CPB2
SCHEMBL1445009 0.93 HDAC4 (0.51) HDAC4HDAC1EPHX1SMN1; SMN2CPB2
SCHEMBL4257792 0.92 HDAC4 (0.49) HDAC4HDAC1EPHX1SMN1; SMN2CPB2
SCHEMBL4257798 0.92 HDAC4 (0.49) HDAC4HDAC1EPHX1SMN1; SMN2CPB2
SCHEMBL497997 0.85 HDAC4 (0.55) HDAC4HDAC1EPHX1SMN1; SMN2HDAC6
SCHEMBL15563296 0.85 HDAC4 (0.55) HDAC4HDAC1EPHX1SMN1; SMN2HDAC6
SCHEMBL2808340 0.81 HDAC4 (0.49) HDAC4HDAC1EPHX1SMN1; SMN2HDAC6
SCHEMBL2808344 0.81 HDAC4 (0.49) HDAC4HDAC1EPHX1SMN1; SMN2HDAC6
SCHEMBL8158076 0.80 HDAC4 (0.47) HDAC4HDAC1EPHX1SMN1; SMN2HDAC6
SCHEMBL5740543 0.78 HDAC4 (0.47) HDAC4HDAC1EPHX1SMN1; SMN2HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1615949-A1 PROCESS FOR THE PREPARATION OF MACROCYCLIC COMPOUNDS BY RUTHENIUM COMPLEX CATALYSED METATHESIS REACTION Boehringer Ingelheim International GmbH (DE) 2006-01-18 EP disclosed
WO-2004089974-A1 PROCESS FOR THE PREPARATION OF MACROCYCLIC COMPOUNDS BY RUTHENIUM COMPLEX CATALYSED METATHESIS REACTION BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2004-10-21 WO disclosed