Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5458369 | 0.92 | DPP4 (0.48) | DPP4POLBDPP9DPP8RAB9A | |
| SCHEMBL5453642 | 0.81 | DPP4 (0.46) | DPP4DPP9DPP8MAPTTP53 | |
| Hydrochloric Acid SCHEMBL5446360 | 0.81 | DPP4 (0.56) | DPP4DPP9DPP8RAB9ANPC1 | |
| SCHEMBL5451962 | 0.80 | DPP4 (0.45) | DPP4DPP9DPP8MAPTTP53 | |
| SCHEMBL5447087 | 0.80 | DPP4 (0.43) | DPP4DPP9DPP8ALDH1A1MAPT | |
| SCHEMBL5445046 | 0.79 | DPP4 (0.42) | DPP4POLBMAPK1ATMDPP9 | |
| SCHEMBL4113112 | 0.79 | DPP4 (0.66) | DPP4DPP9DPP8SMN1; SMN2KMT2A | |
| SCHEMBL5454715 | 0.78 | DPP4 (0.47) | DPP4DPP9DPP8 | |
| SCHEMBL5451905 | 0.78 | DPP4 (0.48) | DPP4DPP9DPP8 | |
| SCHEMBL5740578 | 0.77 | DPP4 (0.40) | DPP4DPP9DPP8RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678138-A1 | PYRIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | Takeda Pharmaceutical Company Limited (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042488-A1 | PYRIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-05-12 | — | — | WO | disclosed |