Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5654083 | 0.93 | CA1 (0.52) | CA1CA2SIRT5PTGER4SIRT1 | |
| SCHEMBL5654632 | 0.93 | SIRT5 (0.51) | CA1CA2PSMB5SIRT5PTGER4 | |
| SCHEMBL5653753 | 0.90 | NR1H4 (0.49) | CA1CA2SIRT5PTGER4SIRT1 | |
| SCHEMBL5654264 | 0.88 | CA1 (0.47) | CA1CA2SIRT5PTGER4SIRT1 | |
| SCHEMBL5653554 | 0.85 | SIRT5 (0.46) | CA1CA2SIRT5PTGER4SIRT1 | |
| SCHEMBL5740058 | 0.84 | HDAC1 (0.51) | CA1CA2PTGER4 | |
| SCHEMBL5653258 | 0.84 | KLK7 (0.51) | SIRT5SIRT1SIRT2SIRT3 | |
| SCHEMBL5657104 | 0.83 | PTGER4 (0.47) | CA1CA2SIRT5PTGER4SIRT1 | |
| SCHEMBL5739335 | 0.83 | PTGER4 (0.44) | CA1CA2SIRT5PTGER4SIRT1 | |
| SCHEMBL27676042 | 0.83 | PTGER4 (0.54) | CA1CA2SIRT5PTGER4FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697337-A2 | ORNITHINE DERIVATIVES AS PROSTAGLANDIN-E2-AGONISTS OR ANTAGONISTS | Astellas Pharma Inc. (JP) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061475-A2 | ORNITHINE DERIVATIVES AS PROSTAGLANDIN E2 AGONISTS OR ANTAGONISTS | ASTELLAS PHARMA INC. (JP) | 2005-07-07 | — | — | WO | disclosed |