Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 13/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740309 | 0.86 | KDR (0.54) | EGFRERBB2KDRRET | |
| SCHEMBL1460895 | 0.85 | KDR (0.67) | EGFRERBB2KDR | |
| SCHEMBL5740358 | 0.84 | EGFR (0.66) | EGFRERBB2KDRRET | |
| SCHEMBL5740103 | 0.83 | KDR (0.59) | EGFRKDR | |
| SCHEMBL5739560 | 0.82 | KDR (0.48) | EGFRERBB2KDR | |
| SCHEMBL5740776 | 0.82 | KDR (0.53) | EGFRKDR | |
| SCHEMBL5738812 | 0.81 | KDR (0.49) | EGFRKDR | |
| SCHEMBL5739951 | 0.81 | KDR (0.71) | EGFRKDR | |
| SCHEMBL5739719 | 0.81 | KDR (0.57) | EGFRKDR | |
| SCHEMBL5740556 | 0.80 | KDR (0.62) | EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |