Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 20/20 | 1.00 |
| ▸ | DRD2 | P14416 | 17/20 | 1.00 |
| ▸ | HTR2A | P28223 | 19/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5396017 | 0.90 | HTR1A (1.00) | HTR1AKCNH2DRD2HTR2A | |
| SCHEMBL5737844 | 0.85 | HTR1A (0.73) | HTR1AKCNH2DRD2HTR2A | |
| SCHEMBL5738207 | 0.80 | HTR1A (1.00) | HTR1AKCNH2DRD2HTR2A | |
| SCHEMBL6400159 | 0.77 | HTR1A (0.75) | HTR1AKCNH2DRD2HTR2A | |
| SCHEMBL6405011 | 0.76 | HTR1A (0.76) | HTR1AKCNH2DRD2HTR2A | |
| SCHEMBL15788660 | 0.76 | HTR1A (1.00) | HTR1ADRD2HTR2A | |
| SCHEMBL27922203 | 0.76 | HTR1A (1.00) | HTR1ADRD2HTR2A | |
| SCHEMBL27922201 | 0.76 | HTR1A (1.00) | HTR1ADRD2HTR2A | |
| SCHEMBL5740590 | 0.76 | HTR1A (0.67) | HTR1AKCNH2DRD2HTR2A | |
| SCHEMBL6405936 | 0.76 | HTR1A (0.76) | HTR1AKCNH2DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697334-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2006-09-06 | — | — | EP | disclosed |
| US-20050282819-A1 | Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia | GRAHAM JAMES M | 2005-12-22 | — | — | US | disclosed |
| WO-2005056540-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282819-A1 | Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia | CHRM1, CHRM2, CHRM5 | HTR1A 61/4885KCNH2 114/4885DRD2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.