Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.71 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.62 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29913697 | 0.83 | CRBN (0.72) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL27362185 | 0.83 | CRBN (0.72) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL29913826 | 0.83 | CRBN (0.72) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL29913668 | 0.83 | CRBN (0.72) | CRBNDDB1IKZF3BRD4 | |
| Trifluoroacetic Acid SCHEMBL30635277 | 0.82 | CRBN (0.63) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL20811963 | 0.82 | CRBN (0.74) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL4778728 | 0.82 | CRBN (0.74) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL23267776 | 0.81 | CRBN (0.72) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL20811955 | 0.81 | CRBN (0.72) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL17169744 | 0.81 | CRBN (1.00) | CRBNDDB1IKZF3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1004580-B1 | Imides as inhibitors of TNF alpha | CELGENE CORP (US) | 2006-12-20 | — | — | EP | claimed |
| EP-1477486-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2004-11-17 | — | — | EP | claimed |
| EP-1004580-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | claimed |
| EP-1004580-B1 | Imides as inhibitors of TNF alpha | CELGENE CORP (US) | 2006-12-20 | — | — | EP | disclosed |
| EP-1477486-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2004-11-17 | — | — | EP | disclosed |
| US-6200987-B1 | ADMINISTERING AS TUMOR NECROSIS FACTOR INHIBITORS; CACHEXIA, ENDOTOXIN SHOCK; RETROVIRUS VIRICIDES | CELGENE CORPORATION | 2001-03-13 | — | — | US | disclosed |
| US-6075041-A | TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 2000-06-13 | — | — | US | disclosed |
| EP-1004572-A2 | Amines as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-1004580-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-1004581-A2 | Process for the preparation of thalidomide | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| US-5877200-A | Cyclic amides | CELGENE CORPORATION (US) | 1999-03-02 | — | — | US | disclosed |
| US-5698579-A | INHIBITOR OF TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-16 | — | — | US | disclosed |
| US-5605914-A | INHIBITORS OF TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |