Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 15/20 | 0.78 |
| ▸ | CYP1B1 | Q16678 | 15/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 14/20 | 0.78 |
| ▸ | PDE5A | O76074 | 4/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.78 |
| ▸ | NPC1 | O15118 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | TP53 | P04637 | 2/20 | 0.78 |
| ▸ | POLB | P06746 | 2/20 | 0.78 |
| ▸ | RAB9A | P51151 | 2/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | PKM | P14618 | 1/20 | 0.78 |
| ▸ | TSHR | P16473 | 1/20 | 0.78 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.78 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.78 |
| ▸ | THPO | P40225 | 1/20 | 0.78 |
| ▸ | MTOR | P42345 | 1/20 | 0.78 |
| ▸ | BLM | P54132 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rutaecarpine SCHEMBL29693598 | 0.88 | CYP1A1 (1.00) | CYP1A1CYP1B1CYP1A2PDE5AKDM4E | |
| Rutaecarpine SCHEMBL288507 | 0.88 | CYP1A1 (1.00) | CYP1A1CYP1B1CYP1A2PDE5AKDM4E | |
| Rutaecarpine SCHEMBL29406533 | 0.88 | CYP1A1 (1.00) | CYP1A1CYP1B1CYP1A2PDE5AKDM4E | |
| SCHEMBL15500023 | 0.81 | CYP1A1 (0.76) | CYP1A1CYP1B1CYP1A2PDE5AKDM4E | |
| SCHEMBL14297679 | 0.81 | CYP1A1 (1.00) | CYP1A1CYP1B1CYP1A2PDE5AKDM4E | |
| SCHEMBL25150530 | 0.79 | CYP1A1 (0.78) | CYP1A1CYP1B1CYP1A2PDE5AKDM4E | |
| SCHEMBL30268975 | 0.78 | BCHE (0.70) | CYP1A1CYP1B1CYP1A2PDE5AKDM4E | |
| SCHEMBL25219690 | 0.78 | BCHE (0.70) | CYP1A1CYP1B1CYP1A2PDE5AKDM4E | |
| SCHEMBL14316571 | 0.77 | CYP1A1 (0.70) | CYP1A1CYP1B1CYP1A2PDE5AKDM4E | |
| SCHEMBL11047610 | 0.77 | CYP1A1 (0.78) | CYP1A1CYP1B1CYP1A2PDE5AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397361-B1 | CARBOLINE DERIVATIVES AS PDEV INHIBITORS | LILLY ICOS LLC (US) | 2006-08-09 | — | — | EP | disclosed |
| US-6984641-B2 | Carboline derivatives as PDE5 inhibitors | LILLY ICOS LLC. (US) | 2006-01-10 | — | — | US | disclosed |
| US-20040171830-A1 | Carboline derivatives as pdev inhibitors | LILLY ICOS LLC | 2004-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171830-A1 | Carboline derivatives as pdev inhibitors | PDE3B, PDE3A, PDE2A | CYP1A1 2658/4885CYP1B1 2386/4885CYP1A2 1785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.