Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 4/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742129 | 0.90 | KDM4E (0.55) | AGPAT2KDM4EHSD17B10ALDH1A1MCHR1 | |
| SCHEMBL5740513 | 0.89 | KDM4E (0.44) | AGPAT2KDM4EHSD17B10MCHR1ROCK2 | |
| SCHEMBL5744288 | 0.89 | KDM4E (0.56) | AGPAT2KDM4EHSD17B10ALDH1A1MCHR1 | |
| SCHEMBL5742792 | 0.89 | AGPAT2 (0.59) | AGPAT2ACP1TP53MAPTHRH4 | |
| SCHEMBL5741884 | 0.88 | AGPAT2 (0.52) | AGPAT2MCHR1ACP1ROCK2LMNA | |
| SCHEMBL5741026 | 0.88 | AGPAT2 (0.52) | AGPAT2MCHR1ACP1ROCK2LMNA | |
| SCHEMBL5742859 | 0.87 | AGPAT2 (0.63) | AGPAT2KDM4EACP1TP53MAPT | |
| SCHEMBL5743344 | 0.85 | AGPAT2 (0.53) | AGPAT2ACP1ROCK2MAPTHRH4 | |
| SCHEMBL5741974 | 0.85 | AGPAT2 (0.53) | AGPAT2ACP1ROCK2MAPTHRH4 | |
| SCHEMBL5742786 | 0.85 | AGPAT2 (0.64) | AGPAT2ACP1TP53MAPTHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |