Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740098 | 0.95 | ALDH1A1 (0.41) | HSD17B10ALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL5739045 | 0.94 | ALDH1A1 (0.41) | HSD17B10ALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL5738339 | 0.88 | ALDH1A1 (0.41) | HSD17B10ALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL4044556 | 0.87 | PDE4A (0.41) | HSD17B10ALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL14470113 | 0.86 | ALDH1A1 (0.40) | HSD17B10ALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL4049523 | 0.84 | HSD17B10 (0.40) | HSD17B10ALDH1A1MAPTTSHRPDE4A | |
| SCHEMBL4044212 | 0.84 | KDR (0.47) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL5740055 | 0.83 | MAPT (0.35) | HSD17B10ALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL4044576 | 0.83 | PDE4A (0.39) | HSD17B10ALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL4041795 | 0.81 | PDE4A (0.34) | HSD17B10ALDH1A1MAPTL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |