Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5513275 | 0.87 | KDR (0.68) | KDREGFRMAP2K1MAPK14ERBB2 | |
| SCHEMBL5739951 | 0.82 | KDR (0.71) | KDREGFR | |
| SCHEMBL5740240 | 0.82 | KDR (0.53) | KDREGFRMAPK14ERBB2 | |
| SCHEMBL5739861 | 0.81 | KDR (0.59) | KDREGFR | |
| SCHEMBL5740324 | 0.81 | KDR (0.54) | KDREGFRMAP2K1MAPK14ERBB2 | |
| SCHEMBL5738277 | 0.80 | KDR (0.57) | KDREGFRMAP2K1MAPK14 | |
| SCHEMBL5740421 | 0.79 | KDR (0.52) | KDREGFRMAPK14 | |
| SCHEMBL5740244 | 0.79 | KDR (0.54) | KDREGFRMAP2K1MAPK14ERBB2 | |
| SCHEMBL5730197 | 0.79 | KDR (0.56) | KDREGFRMAPK14 | |
| SCHEMBL5739893 | 0.79 | KDR (0.71) | KDREGFRMAP2K1MAPK14ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |