Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 3/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2747017 | 0.95 | KCNJ1 (0.73) | KCNJ1KCNH2RECQLALDH1A1KDM4E | |
| SCHEMBL1876940 | 0.82 | RECQL (0.72) | KCNJ1KCNH2RECQLALDH1A1KDM4E | |
| SCHEMBL2384676 | 0.80 | RECQL (0.70) | KCNJ1KCNH2RECQLALDH1A1KDM4E | |
| SCHEMBL30643815 | 0.80 | CYP2C19 (0.64) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL76204 | 0.80 | CYP2C19 (0.64) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL6607225 | 0.79 | RECQL (0.68) | KCNJ1KCNH2RECQLALDH1A1KDM4E | |
| SCHEMBL12611028 | 0.79 | KMT2A (0.90) | KCNJ1KCNH2RECQLALDH1A1KDM4E | |
| SCHEMBL4987745 | 0.78 | RECQL (0.67) | KCNJ1KCNH2RECQLALDH1A1KDM4E | |
| SCHEMBL1369959 | 0.78 | CYP2C19 (0.62) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL27861234 | 0.78 | CYP2C19 (0.62) | ALDH1A1KDM4EKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| EP-1682531-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |
| WO-2005042518-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2005-05-12 | — | — | WO | disclosed |