Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1876940 | 0.88 | RECQL (0.72) | RECQLKCNJ1KCNH2ALDH1A1LMNA | |
| SCHEMBL2384676 | 0.86 | RECQL (0.70) | RECQLKCNJ1KCNH2ALDH1A1LMNA | |
| SCHEMBL3673014 | 0.85 | SMN1; SMN2 (0.58) | ALDH1A1LMNAKMT2APOLBMEN1 | |
| SCHEMBL2747017 | 0.84 | KCNJ1 (0.73) | RECQLKCNJ1KCNH2ALDH1A1LMNA | |
| SCHEMBL4987745 | 0.84 | RECQL (0.67) | RECQLKCNJ1KCNH2ALDH1A1LMNA | |
| SCHEMBL3649483 | 0.83 | SIGMAR1 (0.64) | RECQLKCNJ1KCNH2ALDH1A1LMNA | |
| SCHEMBL3039451 | 0.80 | KCNJ1 (0.53) | RECQLKCNJ1KCNH2ALDH1A1LMNA | |
| SCHEMBL6944079 | 0.80 | DPP8 (0.52) | RECQLKCNJ1KCNH2ALDH1A1LMNA | |
| SCHEMBL5741299 | 0.79 | KCNJ1 (0.67) | RECQLKCNJ1KCNH2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL5724126 | 0.79 | KCNJ1 (0.52) | RECQLKCNJ1KCNH2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1821236-B | Therapeutic heterocyclic compounds | ASTRAZENECA AB | 2010-06-23 | — | — | CN | disclosed |
| CN-100509794-C | Therapeutic heterocyclic compounds | ASTRAZENECA AB (SE) | 2009-07-08 | — | — | CN | disclosed |
| CN-100460402-C | Therapeutic benzopyranone compounds used as intermediates. | ASTRAZENECA AB (SE) | 2009-02-11 | — | — | CN | disclosed |
| CN-100384833-C | Therapeutic chroman compounds | ASTRAZENECA AB (SE) | 2008-04-30 | — | — | CN | disclosed |
| CN-1821236-A | Therapeutic heterocyclic compounds | ASTRAZENECA AB (SE) | 2006-08-23 | — | — | CN | disclosed |
| CN-1740168-A | Therapeutic benzopyranone compounds used as intermediates. | ASTRAZENECA AB (SE) | 2006-03-01 | — | — | CN | disclosed |
| CN-1610671-A | Therapeutic quinoline compounds having 5-HT-antagonistic properties | ASTRAZENECA AB (SE) | 2005-04-27 | — | — | CN | disclosed |
| CN-1608054-A | Therapeutic quinolone compounds having 5-HT-antagonistic properties | ASTRAZENECA AB (SE) | 2005-04-20 | — | — | CN | disclosed |
| CN-1592745-A | Therapeutic chromone compounds | ASTRAZENECA AB (SE) | 2005-03-09 | — | — | CN | disclosed |
| CN-1527827-A | Therapeutic heterocyclic compounds | — | 2004-09-08 | — | — | CN | disclosed |
| EP-1451158-A1 | THERAPEUTIC QUINOLINE COMPOUNDS WITH 5-HT-ANTAGONISTIC PROPERTIES | AstraZeneca AB (SE) | 2004-09-01 | — | — | EP | disclosed |
| CN-1524077-A | Therapeutic chroman compounds | — | 2004-08-25 | — | — | CN | disclosed |
| EP-1353913-A2 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | AstraZeneca AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1353914-A2 | THERAPEUTIC CHROMONE COMPOUNDS | AstraZeneca AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1353915-A2 | THERAPEUTIC CHROMAN COMPOUNDS | AstraZeneca AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| WO-2003037871-A1 | THERAPEUTIC QUINOLONE COMPOUNDS WITH 5-HT-ANTAGONISTIC PROPERTIES | ASTRAZENECA AB (SE) | 2003-05-08 | — | — | WO | disclosed |
| WO-2003037872-A1 | THERAPEUTIC QUINOLINE COMPOUNDS WITH 5-HT-ANTAGONISTIC PROPERTIES | ASTRAZENECA AB (SE) | 2003-05-08 | — | — | WO | disclosed |
| WO-2002055013-A2 | THERAPEUTIC CHROMONE COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-18 | — | — | WO | disclosed |
| WO-2002055012-A2 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-18 | — | — | WO | disclosed |
| WO-2002055014-A2 | THERAPEUTIC CHROMAN COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-18 | — | — | WO | disclosed |