Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GLS | O94925 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741330 | 1.00 | HMGCR (0.35) | HMGCRSMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL5743772 | 0.88 | HMGCR (0.37) | HMGCRSMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL5741396 | 0.88 | HMGCR (0.37) | HMGCRSMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL5743770 | 0.88 | HMGCR (0.37) | HMGCRSMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL5741400 | 0.88 | HMGCR (0.37) | HMGCRSMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL5743144 | 0.86 | ALDH1A1 (0.38) | HMGCRSMN1; SMN2ALDH1A1L3MBTL1MAPT | |
| SCHEMBL5743150 | 0.86 | ALDH1A1 (0.38) | HMGCRSMN1; SMN2ALDH1A1L3MBTL1MAPT | |
| SCHEMBL5732070 | 0.78 | HMGCR (0.45) | HMGCR | |
| SCHEMBL5732063 | 0.78 | HMGCR (0.45) | HMGCR | |
| SCHEMBL5740858 | 0.77 | HMGCR (0.44) | HMGCRSMN1; SMN2ALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727541-A1 | IMIDAZOLE-BASED HMG-COA REDUCTASE INHIBITORS | Warner-Lambert Company LLC (US) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005079790-A1 | IMIDAZOLE-BASED HMG-COA REDUCTASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-09-01 | — | — | WO | disclosed |