Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4946697 | 0.86 | IKBKB (0.58) | PRMT5IKBKB | |
| SCHEMBL5741166 | 0.85 | IKBKB (0.41) | IKBKBHPGDSALOX5APFEN1USP30 | |
| SCHEMBL4947301 | 0.83 | IKBKB (0.65) | IKBKB | |
| SCHEMBL5741008 | 0.82 | USP30 (0.44) | PRMT5IKBKBHPGDSGPR119ALOX5AP | |
| SCHEMBL4939088 | 0.81 | IKBKB (0.53) | PRMT5IKBKBHPGDSGPR119ALOX5AP | |
| SCHEMBL5743013 | 0.80 | ALOX5AP (0.40) | IKBKBHPGDSALOX5APFEN1USP30 | |
| SCHEMBL5743095 | 0.80 | ALOX5AP (0.39) | IKBKBHPGDSALOX5APFEN1USP30 | |
| SCHEMBL5741980 | 0.78 | ALOX5AP (0.39) | IKBKBHPGDSALOX5APFEN1USP30 | |
| SCHEMBL4938772 | 0.77 | IKBKB (0.48) | PRMT5IKBKB | |
| SCHEMBL4947768 | 0.77 | IKBKB (0.48) | PRMT5IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |