Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741166 | 0.91 | IKBKB (0.41) | ALOX5APFEN1IKBKBALDH1A1MEN1 | |
| SCHEMBL5741980 | 0.91 | ALOX5AP (0.39) | ALOX5APFEN1IKBKBALDH1A1MEN1 | |
| SCHEMBL5743013 | 0.91 | ALOX5AP (0.40) | ALOX5APFEN1IKBKBALDH1A1MEN1 | |
| SCHEMBL5741514 | 0.80 | PRMT5 (0.44) | ALOX5APFEN1IKBKBHPGDSJAK2 | |
| SCHEMBL5741008 | 0.79 | USP30 (0.44) | ALOX5APFEN1IKBKBALDH1A1MEN1 | |
| SCHEMBL4944907 | 0.78 | IKBKB (0.57) | IKBKB | |
| SCHEMBL5742800 | 0.76 | ALDH1A1 (0.45) | ALOX5APFEN1ALDH1A1MEN1MAPT | |
| SCHEMBL5741045 | 0.75 | ALOX5AP (0.42) | ALOX5APFEN1ALDH1A1MEN1MAPT | |
| SCHEMBL4946551 | 0.73 | IKBKB (0.70) | IKBKBSMARCA2SMARCA4PBRM1 | |
| SCHEMBL5743203 | 0.72 | HPGDS (0.39) | ALOX5APFEN1IKBKBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |