Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | AIP | O00170 | 1/20 | 0.34 |
| ▸ | SGTA | O43765 | 1/20 | 0.34 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.34 |
| ▸ | STIP1 | P31948 | 1/20 | 0.34 |
| ▸ | PPP5C | P53041 | 1/20 | 0.34 |
| ▸ | DNAJC7 | Q99615 | 1/20 | 0.34 |
| ▸ | STUB1 | Q9UNE7 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740793 | 0.86 | KDM4E (0.38) | ALDH1A1MAPTHPGDGAAAIP | |
| SCHEMBL5738978 | 0.86 | TNIK (0.41) | ALDH1A1MAPTHPGDGAAAIP | |
| SCHEMBL5739488 | 0.86 | MAPT (0.38) | ALDH1A1MAPTHPGDGAAAIP | |
| SCHEMBL5741212 | 0.85 | TNIK (0.37) | ALDH1A1MAPTHPGDGAAAIP | |
| SCHEMBL5741298 | 0.85 | BRD4 (0.39) | ALDH1A1MAPTHPGDGAAAIP | |
| SCHEMBL5740778 | 0.83 | MAPT (0.39) | ALDH1A1MAPTHPGDGAATNIK | |
| SCHEMBL5740318 | 0.83 | MAPT (0.36) | ALDH1A1MAPTHPGDGAAAIP | |
| SCHEMBL5741596 | 0.83 | MAPT (0.34) | ALDH1A1MAPTHPGDGAAAIP | |
| SCHEMBL5739314 | 0.82 | PTPN5 (0.38) | ALDH1A1MAPTHPGDGAATNIK | |
| SCHEMBL5740626 | 0.82 | TNIK (0.37) | ALDH1A1MAPTHPGDGAAAIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406891-B1 | THIOCHROMENONES USED TO COMBAT PAINFUL CONDITIONS AND NEURODEGENERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2006-03-22 | — | — | EP | disclosed |
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | BAYER HEALTHCARE AG (DE) | 2005-01-13 | — | — | US | disclosed |
| EP-1406891-A1 | THIOCHROMENONES USED TO COMBAT PAINFUL CONDITIONS AND NEURODEGENERATIVE DISEASES | Bayer HealthCare AG (DE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003053955-A1 | THIOCHROMENONES USED TO COMBAT PAINFUL CONDITIONS AND NEURODEGENERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | HTT, HMOX1, SNCA | ALDH1A1 1088/4885MAPT 29/4885HPGD 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.