Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.64 |
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740201 | 0.90 | EGFR (0.75) | EGFRERBB2KDR | |
| SCHEMBL4044543 | 0.87 | EGFR (0.81) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL5740630 | 0.86 | KDR (0.61) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL5740882 | 0.83 | EGFR (0.72) | EGFRERBB2 | |
| SCHEMBL5738521 | 0.82 | EGFR (0.54) | EGFRERBB2KDR | |
| SCHEMBL27888134 | 0.82 | EGFR (0.63) | EGFRERBB2KDR | |
| SCHEMBL4224497 | 0.79 | EGFR (0.71) | EGFRERBB2KDR | |
| SCHEMBL5740085 | 0.79 | EGFR (0.62) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL5738803 | 0.79 | EGFR (0.60) | EGFRERBB2KDR | |
| SCHEMBL4052320 | 0.78 | EGFR (1.00) | EGFRERBB2KDRMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |