Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DDO | Q99489 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818202 | 0.91 | HCAR2 (0.52) | CYP2C9CYP2C19HCAR2POLBALDH1A1 | |
| SCHEMBL7396814 | 0.78 | CYP2C9 (0.49) | CYP2C9CYP2C19HCAR2POLBALDH1A1 | |
| SCHEMBL18485279 | 0.76 | SIRT2 (0.50) | CYP2C9CYP2C19KDM4ERAB9AGAA | |
| SCHEMBL30543639 | 0.72 | HCAR2 (0.57) | CYP2C9CYP2C19HCAR2POLBALDH1A1 | |
| SCHEMBL20992876 | 0.72 | HCAR2 (0.57) | CYP2C9CYP2C19HCAR2POLBALDH1A1 | |
| SCHEMBL13451125 | 0.71 | TPMT (0.43) | CYP2C9CYP2C19ALDH1A1KDM4EMEN1 | |
| Nitric Acid SCHEMBL5739035 | 0.71 | HCAR2 (0.47) | CYP2C9CYP2C19HCAR2POLBALDH1A1 | |
| SCHEMBL27591998 | 0.70 | HCAR2 (0.46) | CYP2C9CYP2C19HCAR2POLBALDH1A1 | |
| SCHEMBL27632854 | 0.70 | KDM6B (0.49) | CYP2C9HCAR2POLBALDH1A1KDM4E | |
| SCHEMBL31113334 | 0.70 | CYP2C9 (0.43) | CYP2C9CYP2C19HCAR2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1120419-B1 | DERIVATIVES OF ISOSORBID MONONITRATE, UTILIZATION AS VASODILATOR AGENTS WITH REDUCED TOLERANCE | LACER SA (ES) | 2006-04-19 | — | — | EP | claimed |