Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DDO | Q99489 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11779027 | 0.80 | CASP6 (0.41) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL7817677 | 0.76 | HCAR2 (0.59) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7674347 | 0.76 | HCAR2 (0.53) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL30777432 | 0.76 | HCAR2 (0.59) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7225354 | 0.74 | HCAR2 (0.57) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7471695 | 0.74 | HCAR2 (0.57) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1244630 | 0.74 | KDM4E (0.57) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL846393 | 0.74 | CYP2C9 (0.61) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL30281282 | 0.74 | CYP2C9 (0.61) | HCAR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1641703 | 0.74 | FOLH1 (0.58) | KMT2ACYP2C9TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1564686-A | 8-amino- [1,2,4] triazolo [1, 5-a ] pyridine-6-carboxamides | HOFFMANN LA ROCHE (CH) | 2005-01-12 | — | — | CN | disclosed |