Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2891581 | 0.91 | CYP3A4 (0.47) | GAACYP3A4RXFP1CTDSP1TDP1 | |
| SCHEMBL5741042 | 0.86 | MAPT (0.51) | GAARXFP1TSHRKMT2AMEN1 | |
| SCHEMBL2895250 | 0.82 | CYP3A4 (0.51) | GAACYP3A4RXFP1CTDSP1TDP1 | |
| SCHEMBL2889410 | 0.81 | RXRA (0.36) | GAACYP3A4RXFP1KMT2AMEN1 | |
| SCHEMBL2893164 | 0.80 | GAA (0.36) | GAACYP3A4RXFP1CTDSP1TDP1 | |
| SCHEMBL5739438 | 0.78 | MAPT (0.53) | GAAL3MBTL1TSHRKMT2AMEN1 | |
| SCHEMBL2895597 | 0.75 | CYP3A4 (0.49) | GAACYP3A4RXFP1CTDSP1TDP1 | |
| SCHEMBL5739564 | 0.74 | CYP3A4 (0.42) | GAACYP3A4RXFP1CTDSP1TDP1 | |
| SCHEMBL2893476 | 0.73 | GRM5 (0.37) | — | |
| SCHEMBL2898035 | 0.72 | CYP3A4 (0.37) | GAACYP3A4RXFP1CTDSP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |