Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 20/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989486 | 0.77 | GRM5 (0.58) | GRM5 | |
| SCHEMBL1691942 | 0.76 | GRM5 (0.57) | GRM5 | |
| SCHEMBL16390667 | 0.75 | GRM5 (0.49) | GRM5 | |
| SCHEMBL5744089 | 0.73 | GRM5 (0.52) | GRM5 | |
| SCHEMBL990721 | 0.72 | GRM5 (0.56) | GRM5 | |
| SCHEMBL990033 | 0.72 | GRM5 (0.58) | GRM5 | |
| SCHEMBL990047 | 0.70 | GRM5 (0.53) | GRM5 | |
| SCHEMBL2813707 | 0.68 | GRM5 (0.56) | GRM5 | |
| SCHEMBL1897459 | 0.68 | GRM5 (0.56) | GRM5 | |
| SCHEMBL992059 | 0.68 | GRM5 (0.57) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453512-B1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | NOVARTIS AG (CH) | 2006-05-31 | — | — | EP | claimed |