Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 17/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990047 | 0.82 | GRM5 (0.53) | GRM5 | |
| SCHEMBL14119620 | 0.79 | GRM5 (0.54) | GRM5 | |
| SCHEMBL3627130 | 0.78 | GRM5 (0.58) | GRM5 | |
| SCHEMBL990085 | 0.78 | GRM5 (0.58) | GRM5 | |
| SCHEMBL3971263 | 0.78 | GRM5 (0.58) | GRM5 | |
| SCHEMBL990721 | 0.74 | GRM5 (0.56) | GRM5 | |
| SCHEMBL5742587 | 0.73 | GRM5 (0.49) | GRM5 | |
| SCHEMBL990697 | 0.72 | GRM5 (0.53) | GRM5 | |
| SCHEMBL990033 | 0.71 | GRM5 (0.58) | GRM5 | |
| SCHEMBL16390667 | 0.70 | GRM5 (0.49) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453512-B1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | NOVARTIS AG (CH) | 2006-05-31 | — | — | EP | claimed |