SCHEMBL5742920

SCHEMBL5742920

C=Cc1ccc(S(=O)(=O)N2CCN(CC3(NC(=O)OCC)CCN(C(=O)OC(C)(C)C)CC3)C(=O)C2)cc1

nearest known ligand 0.44

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 14/20 0.44
F13A1 P00488 11/20 0.44
TGM1 P22735 8/20 0.44
POLB P06746 1/20 0.38
PKM P14618 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TGM3 Q08188 1/20 0.37
NAMPT P43490 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5742042 0.85 F13A1 (0.38) TGM2F13A1TGM1POLBPKM
SCHEMBL5741924 0.84 MAPT (0.42) TGM2F13A1TGM1POLBPKM
SCHEMBL5740527 0.83 ATM (0.39) TGM2F13A1TGM1SMN1; SMN2
SCHEMBL5741976 0.81 ATM (0.37) TGM2F13A1TGM1POLBPKM
SCHEMBL5855055 0.81 CYP2C9 (0.34) TGM2F13A1TGM1POLBSMN1; SMN2
Hydrochloric Acid SCHEMBL5742036 0.80 ATM (0.36) TGM2F13A1TGM1POLBPKM
SCHEMBL5740518 0.80 ATM (0.36) TGM2F13A1TGM1POLBTGM3
SCHEMBL5743483 0.79 ATM (0.36) TGM2F13A1TGM1POLBPKM
SCHEMBL5741290 0.78 CYP1A2 (0.37) TGM2F13A1TGM1SMN1; SMN2
SCHEMBL5740189 0.76 SMN1; SMN2 (0.39) TGM2F13A1TGM1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7109200-B2 Carbamate derivatives, process for producing the same and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-09-19 US disclosed
EP-1340753-B1 CARBAMATE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2006-01-11 EP disclosed
US-20040038986-A1 Carbamate derivatives, process for producing the same and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-02-26 US disclosed
EP-1340753-A1 CARBAMATE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2003-09-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040038986-A1 Carbamate derivatives, process for producing the same and use thereof CFH, F11, F2 TGM2 1508/4885F13A1 18/4885TGM1 327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.