Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | REV1 | Q9UBZ9 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | AIP | O00170 | 1/20 | 0.43 |
| ▸ | SGTA | O43765 | 1/20 | 0.43 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.43 |
| ▸ | STIP1 | P31948 | 1/20 | 0.43 |
| ▸ | PPP5C | P53041 | 1/20 | 0.43 |
| ▸ | DNAJC7 | Q99615 | 1/20 | 0.43 |
| ▸ | STUB1 | Q9UNE7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5460925 | 0.86 | FLT3 (0.51) | FLT3POLBREV1MAPTDUSP3 | |
| SCHEMBL5448304 | 0.86 | FLT3 (0.48) | FLT3POLBREV1MAPTDUSP3 | |
| SCHEMBL5453224 | 0.78 | FLT3 (0.64) | FLT3POLBREV1MAPTDUSP3 | |
| SCHEMBL5450835 | 0.72 | POLB (0.62) | FLT3POLBREV1MAPTDUSP3 | |
| SCHEMBL5449204 | 0.72 | FLT3 (0.68) | FLT3POLBREV1MAPTDUSP3 | |
| SCHEMBL3916303 | 0.72 | REV1 (0.79) | FLT3POLBREV1MAPTDUSP3 | |
| SCHEMBL5457919 | 0.72 | FLT3 (0.48) | FLT3POLBREV1MAPTDUSP3 | |
| SCHEMBL5451302 | 0.71 | FLT3 (0.70) | FLT3POLBREV1MAPTDUSP3 | |
| SCHEMBL5455042 | 0.71 | FLT3 (0.70) | FLT3POLBREV1MAPTDUSP3 | |
| SCHEMBL8291584 | 0.71 | REV1 (0.61) | FLT3POLBREV1MAPTDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670804-A2 | HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | GPC Biotech AG (DE) | 2006-06-21 | — | — | EP | claimed |
| WO-2005023818-A2 | HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | GPC BIOTECH AG (DE) | 2005-03-17 | — | — | WO | claimed |