Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5284664 | 0.98 | ALDH1A1 (0.47) | ALDH1A1LMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5302624 | 0.98 | ALDH1A1 (0.47) | ALDH1A1LMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5286590 | 0.98 | ALDH1A1 (0.47) | ALDH1A1LMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5301218 | 0.98 | ALDH1A1 (0.47) | ALDH1A1LMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5817323 | 0.98 | ALDH1A1 (0.47) | ALDH1A1LMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5297855 | 0.98 | ALDH1A1 (0.47) | ALDH1A1LMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5307711 | 0.98 | ALDH1A1 (0.47) | ALDH1A1LMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5295981 | 0.98 | ALDH1A1 (0.47) | ALDH1A1LMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5302861 | 0.98 | ALDH1A1 (0.47) | ALDH1A1LMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5288974 | 0.98 | ALDH1A1 (0.47) | ALDH1A1LMNACYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9999217-B2 | Compositions for stabilizing DNA, RNA, and proteins in blood and other biological samples during shipping and storage at ambient temperatures | BIOMATRICA, INC. (US) | 2018-06-19 | — | — | US | claimed |
| EP-2598660-B1 | COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES | BIOMATRICA INC (US) | 2017-03-15 | — | — | EP | claimed |
| US-20160338342-A1 | COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES | EXACT SCIENCES CORPORATION | 2016-11-24 | — | — | US | claimed |
| US-9376709-B2 | Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures | BIOMATRICA, INC. (US) | 2016-06-28 | — | — | US | claimed |
| EP-2598660-A2 | COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES | Biomatrica, INC. (US) | 2013-06-05 | — | — | EP | claimed |
| US-20120052572-A1 | COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES | EXACT SCIENCES CORPORATION | 2012-03-01 | — | — | US | claimed |
| WO-2012018638-A2 | COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES | BIOMATRICA, INC. (US) | 2012-02-09 | — | — | WO | claimed |
| US-20220032306-A1 | CAPSULE CONTAINMENT OF DRIED REAGENTS | TALIS BIOMEDICAL CORPORATION | 2022-02-03 | — | — | US | disclosed |
| US-20210008559-A1 | CAPSULE CONTAINMENT OF DRIED REAGENTS | TALIS BIOMEDICAL CORPORATION | 2021-01-14 | — | — | US | disclosed |
| US-10207269-B2 | System and method for movement and timing control | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2019-02-19 | — | — | US | disclosed |
| EP-2839260-B1 | FLUIDIC DEVICES AND SYSTEMS FOR SAMPLE PREPARATION OR AUTONOMOUS ANALYSIS | TALIS BIOMEDICAL CORP (US) | 2018-07-18 | — | — | EP | disclosed |
| US-9999217-B2 | Compositions for stabilizing DNA, RNA, and proteins in blood and other biological samples during shipping and storage at ambient temperatures | BIOMATRICA, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| US-9822356-B2 | Fluidic devices and systems for sample preparation or autonomous analysis | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-11-21 | — | — | US | disclosed |
| US-20130309679-A1 | FLUIDIC DEVICES AND SYSTEMS FOR SAMPLE PREPARATION OR AUTONOMOUS ANALYSIS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2013-11-21 | — | — | US | disclosed |
| WO-2013159117-A1 | FLUIDIC DEVICES AND SYSTEMS FOR SAMPLE PREPARATION OR AUTONOMOUS ANALYSIS | SlipChip, LLC (US) | 2013-10-24 | — | — | WO | disclosed |
| WO-2013159116-A1 | FLUIDIC DEVICES FOR BIOSPECIMEN PRESERVATION | UNIVERSITY OF CHICAGO (US) | 2013-10-24 | — | — | WO | disclosed |
| US-20130280725-A1 | FLUIDIC DEVICES FOR BIOSPECIMEN PRESERVATION | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2013-10-24 | — | — | US | disclosed |
| EP-2598660-A2 | COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES | Biomatrica, INC. (US) | 2013-06-05 | — | — | EP | disclosed |
| US-20120052572-A1 | COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES | EXACT SCIENCES CORPORATION | 2012-03-01 | — | — | US | disclosed |
| WO-2012018638-A2 | COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES | BIOMATRICA, INC. (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160338342-A1 | COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES | HNRNPD, HNRNPDL, HNRNPL | ALDH1A1 3155/4885LMNA 542/4885CYP1A2 4597/4885 |
| US-20120052572-A1 | COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES | HNRNPD, HNRNPDL, HNRNPL | ALDH1A1 3155/4885LMNA 542/4885CYP1A2 4597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.