Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692187 | 0.82 | NR1H2 (0.47) | NR1H2NR1H3HSD17B10ALDH1A1KDM4E | |
| SCHEMBL4692190 | 0.79 | NR1H2 (0.45) | NR1H2NR1H3HSD17B10ALDH1A1KDM4E | |
| SCHEMBL5747436 | 0.79 | NR1H2 (0.44) | NR1H2NR1H3HSD17B10ALDH1A1KDM4E | |
| SCHEMBL4691823 | 0.78 | NR1H2 (0.56) | NR1H2NR1H3NTRK1ALDH1A1KDM4E | |
| SCHEMBL5750387 | 0.76 | NR1H2 (0.51) | NR1H2NR1H3NTRK1ALDH1A1KDM4E | |
| SCHEMBL4689410 | 0.75 | NR1H2 (0.51) | NR1H2NR1H3ACVR1HSD17B10ALDH1A1 | |
| SCHEMBL4688674 | 0.71 | NR1H2 (0.56) | NR1H2NR1H3MAPTSMN1; SMN2 | |
| SCHEMBL5737209 | 0.69 | PTGS2 (0.49) | NR1H2NR1H3ALDH1A1MAPTMEN1 | |
| SCHEMBL4690096 | 0.68 | NR1H2 (0.51) | NR1H2NR1H3NTRK1ALDH1A1KDM4E | |
| SCHEMBL4688066 | 0.67 | NR1H2 (0.80) | NR1H2NR1H3ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646626-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2006-04-19 | — | — | EP | claimed |
| WO-2005005417-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2005-01-20 | — | — | WO | claimed |