SCHEMBL5744606

SCHEMBL5744606

NC(CC=CC(=O)O)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 2/20 0.45
CYP2C19 P33261 1/20 0.44
SLC15A1 P46059 1/20 0.42
HDAC3 O15379 1/20 0.39
TNKS O95271 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
TNKS2 Q9H2K2 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
SCN4A P35499 2/20 0.39
GABRR1 P24046 2/20 0.39
GABRR2 P28476 2/20 0.39
BLM P54132 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7238650 0.82 HCAR2 (0.44) HCAR2CYP2C19HDAC3TNKSHDAC4
SCHEMBL3144362 0.82 HCAR2 (0.44) HCAR2CYP2C19HDAC3TNKSHDAC4
SCHEMBL7239259 0.82 HCAR2 (0.44) HCAR2CYP2C19HDAC3TNKSHDAC4
SCHEMBL17460171 0.81 GABBR2 (0.44) HCAR2CYP2C19HDAC3TNKSHDAC4
SCHEMBL17730952 0.78 CYP2C19 (0.62) HCAR2CYP2C19HDAC3TNKSHDAC4
SCHEMBL7374430 0.78 HCAR2 (0.49) HCAR2CYP2C19
SCHEMBL17730949 0.78 CYP2C19 (0.62) HCAR2CYP2C19HDAC3TNKSHDAC4
SCHEMBL17730856 0.76 GABBR2 (0.41) HCAR2CYP2C19HDAC3TNKSHDAC4
SCHEMBL17730855 0.76 GABBR2 (0.41) HCAR2CYP2C19HDAC3TNKSHDAC4
SCHEMBL30715266 0.76 HCAR2 (0.42) HCAR2CYP2C19SLC15A1HDAC3TNKS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1620432-A1 NK-2 ANTAGONIST BASIC LINEAR COMPOUNDS AND FORMULATIONS CONTAINING THEM Menarini Ricerche S.p.A. (IT) 2006-02-01 EP disclosed
WO-2004094412-A1 NK-2 ANTAGONIST BASIC LINEAR COMPOUNDS AND FORMULATIONS CONTAINING THEM MENARINI RICERCHE S.P.A. (IT) 2004-11-04 WO disclosed
EP-0012194-B1 PROCESS FOR THE PREPARATION OF N-CARBOXYALKYL-1-AMINOALKANE DIPHOSPHONIC ACIDS AND CARBOXYALKYLAMINO-PHENYL-METHANE DIPHOSPHONIC ACIDS Benckiser-Knapsack GmbH (DE) 1982-02-03 EP disclosed
EP-0012194-A1 Process for the preparation of N-carboxyalkyl-1-aminoalkane diphosphonic acids and carboxyalkylamino-phenyl-methane diphosphonic acids Benckiser-Knapsack GmbH (DE) 1980-06-25 EP disclosed