Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 3/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909143 | 1.00 | ALDH1A1 (0.55) | ALDH1A1KMT2ALMNAMEN1GRM5 | |
| SCHEMBL3857604 | 1.00 | ALDH1A1 (0.55) | ALDH1A1KMT2ALMNAMEN1GRM5 | |
| SCHEMBL14731432 | 0.92 | ALDH1A1 (0.61) | ALDH1A1KMT2ALMNAMEN1GRM5 | |
| Trifluoroacetic Acid SCHEMBL3857570 | 0.92 | KCNH2 (0.48) | ALDH1A1KMT2ALMNAMEN1GRM5 | |
| SCHEMBL2431433 | 0.92 | GRM5 (0.53) | ALDH1A1KMT2ALMNAMEN1GRM5 | |
| SCHEMBL12426729 | 0.84 | KCNH2 (0.50) | GRM5KDM1AKCNH2L3MBTL3L3MBTL1 | |
| SCHEMBL26944349 | 0.84 | GRM5 (0.54) | ALDH1A1KMT2ALMNAMEN1GRM5 | |
| SCHEMBL5908999 | 0.84 | ALDH1A1 (0.61) | ALDH1A1KMT2ALMNAMEN1GRM5 | |
| SCHEMBL26421666 | 0.83 | KCNH2 (0.44) | GRM5KDM1AKCNH2L3MBTL3L3MBTL1 | |
| SCHEMBL26421617 | 0.83 | ALDH1A1 (0.47) | ALDH1A1GRM5KDM1AKCNH2L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680415-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005035524-A1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENSIS INHIBITORS | ABBOTT LABORATORIES (US) | 2005-04-21 | — | — | WO | disclosed |