SCHEMBL5744992

SCHEMBL5744992

Cc1ccc(NS(=O)(=O)c2c(Cl)sc(Cl)c2Br)cc1O[C@@H]1CCN(C)C1

nearest known ligand 0.54

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 15/20 0.54
LMNA P02545 1/20 0.37
HTR6 P50406 2/20 0.37
STS P08842 1/20 0.37
HTR2C P28335 1/20 0.37
HTR2B P41595 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5744178 1.00 UTS2R (0.54) UTS2RLMNAHTR6STSHTR2C
SCHEMBL5743906 0.91 UTS2R (0.65) UTS2R
SCHEMBL5744589 0.91 UTS2R (0.65) UTS2R
SCHEMBL5743566 0.89 UTS2R (0.65) UTS2RSTS
SCHEMBL5741822 0.83 UTS2R (0.61) UTS2RHTR6HTR2CHTR2B
SCHEMBL5741634 0.83 UTS2R (0.61) UTS2RHTR6HTR2CHTR2B
SCHEMBL5744852 0.82 UTS2R (0.62) UTS2RLMNAHTR6HTR2CHTR2B
SCHEMBL5745120 0.82 UTS2R (0.62) UTS2RLMNAHTR6HTR2CHTR2B
SCHEMBL5744076 0.81 UTS2R (0.63) UTS2R
SCHEMBL8342314 0.80 UTS2R (0.55) UTS2RHTR6HTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1385840-B1 SULFONAMIDES SMITHKLINE BEECHAM CORP (US) 2006-10-04 EP claimed