Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 2/20 | 0.49 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11379644 | 0.85 | HTR1B (0.53) | HTTMAPTHTR1BKCNA3KDM1A | |
| SCHEMBL5748074 | 0.85 | SLC6A4 (0.53) | HTTMAPTHTR1BKCNA3KDM1A | |
| SCHEMBL5747032 | 0.84 | HTR1B (0.49) | HTTMAPTHTR1BKCNA3MCL1 | |
| SCHEMBL5746733 | 0.84 | HTR1B (0.51) | HTTMAPTHTR1BKCNA3KDM1A | |
| SCHEMBL11384305 | 0.83 | HTR1B (0.52) | HTTMAPTHTR1BKCNA3KDM1A | |
| SCHEMBL5747914 | 0.83 | HTR1B (0.52) | HTTMAPTHTR1BKCNA3KDM1A | |
| SCHEMBL5745434 | 0.83 | CYP2D6 (0.50) | HTTMAPTTDP1MEN1KMT2A | |
| SCHEMBL5749009 | 0.82 | HTR1B (0.56) | HTTMAPTHTR1BKCNA3KDM1A | |
| Hydrochloric Acid SCHEMBL11376441 | 0.82 | HTR1B (0.51) | HTTMAPTHTR1BKCNA3KDM1A | |
| SCHEMBL5774116 | 0.82 | HRH3 (0.53) | MAPTTDP1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |