Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HEXA | P06865 | 1/20 | 0.41 |
| ▸ | HEXB | P07686 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746733 | 0.96 | HTR1B (0.51) | HTR1BMAPTHTTADRB2KDM1A | |
| SCHEMBL5747914 | 0.89 | HTR1B (0.52) | HTR1BMAPTHTTKDM1AKCNA3 | |
| SCHEMBL5748300 | 0.88 | HTR1B (0.56) | HTR1BMAPTHTTADRB2KCNA3 | |
| SCHEMBL5748074 | 0.88 | SLC6A4 (0.53) | HTR1BMAPTHTTKDM1AKCNA3 | |
| SCHEMBL5772233 | 0.86 | KDM1A (0.49) | HTR1BMAPTHTTADRB2KDM1A | |
| SCHEMBL5745853 | 0.85 | HTR1B (0.53) | HTR1BHTTADRB2KCNA3HEXA | |
| SCHEMBL5770337 | 0.82 | KDM1A (0.48) | HTR1BMAPTHTTKDM1AKCNA3 | |
| SCHEMBL5745135 | 0.82 | HTT (0.52) | HTR1BMAPTHTTKDM1AKCNA3 | |
| SCHEMBL5746113 | 0.81 | MAPT (0.49) | HTR1BMAPTHTTKDM1AKCNA3 | |
| SCHEMBL11384305 | 0.81 | HTR1B (0.52) | HTR1BMAPTHTTADRB2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |