Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 16/20 | 0.53 |
| ▸ | HTR2B | P41595 | 8/20 | 0.48 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748262 | 0.86 | HTR2C (0.52) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL5743824 | 0.86 | HTR2C (0.56) | HTR2CHTR2BHTR2AHTR6KDM4E | |
| SCHEMBL6711204 | 0.78 | HTR2C (0.56) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL6714062 | 0.78 | HTR2C (0.56) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL10249403 | 0.75 | HTR2C (0.50) | HTR2CHTR2BHTR2AHTR6KDM4E | |
| SCHEMBL5743799 | 0.73 | HTR2C (0.51) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL5747129 | 0.73 | HTR2C (0.56) | HTR2CHTR2BHTR2AHTR6KDM4E | |
| SCHEMBL5744871 | 0.70 | HTR2C (0.52) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL6712007 | 0.69 | HTR2C (0.53) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL6718842 | 0.69 | HTR2C (0.53) | HTR2CHTR2BHTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345942-B9 | PYRAZINOQUINOXALINE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2006-11-15 | — | — | EP | disclosed |
| EP-1345942-B1 | PYRAZINOQUINOXALINE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2006-03-01 | — | — | EP | disclosed |