Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.48 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.44 |
| ▸ | BLK | P51451 | 2/20 | 0.44 |
| ▸ | STK3 | Q13188 | 2/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.44 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5795104 | 0.87 | KDR (0.57) | KDRPIM1ROCK1ROCK2MAP4K4 | |
| SCHEMBL5794432 | 0.87 | KDR (0.63) | KDRPIM1ROCK1ROCK2MAP4K4 | |
| SCHEMBL5749449 | 0.85 | KDR (0.51) | KDRPIM1ROCK1ROCK2MAP4K4 | |
| SCHEMBL5798358 | 0.84 | KDR (0.59) | KDRPIM1ROCK1ROCK2MAP4K4 | |
| SCHEMBL5798745 | 0.82 | KDR (0.49) | KDRPIM1ROCK1ROCK2MAP4K4 | |
| SCHEMBL5746369 | 0.79 | KDR (0.48) | KDRPIM1ROCK1ROCK2MAP4K4 | |
| SCHEMBL1333737 | 0.77 | KDR (0.53) | KDRPIM1ROCK1ROCK2MAP4K4 | |
| SCHEMBL3594664 | 0.75 | KDR (0.68) | KDRPIM1ROCK1ROCK2MAP4K4 | |
| SCHEMBL2732653 | 0.74 | KDR (0.51) | KDRPIM1ROCK1ROCK2MAP4K4 | |
| SCHEMBL2732814 | 0.74 | KDR (0.56) | KDRPIM1ROCK1ROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633710-A1 | ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS | Abbott Laboratories (US) | 2006-03-15 | — | — | EP | claimed |
| WO-2004108672-A1 | ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-16 | — | — | WO | claimed |