Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.49 |
| ▸ | PIM1 | P11309 | 3/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
| ▸ | BLK | P51451 | 2/20 | 0.42 |
| ▸ | STK3 | Q13188 | 2/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.42 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745694 | 0.82 | KDR (0.48) | KDRPIM1ROCK1CLK4CSNK1A1 | |
| SCHEMBL5794432 | 0.78 | KDR (0.63) | KDRPIM1ROCK1CLK4ROCK2 | |
| SCHEMBL5795104 | 0.78 | KDR (0.57) | KDRPIM1ROCK1CLK4ROCK2 | |
| SCHEMBL1333737 | 0.77 | KDR (0.53) | KDRPIM1ROCK1CLK4ROCK2 | |
| SCHEMBL27499554 | 0.77 | ALDH1A1 (0.40) | KDRPRKAA1 | |
| SCHEMBL5749449 | 0.76 | KDR (0.51) | KDRPIM1ROCK1CLK4ROCK2 | |
| SCHEMBL5798358 | 0.75 | KDR (0.59) | KDRPIM1ROCK1CLK4ROCK2 | |
| SCHEMBL27576157 | 0.74 | HNF4A (0.54) | KDRPRKAA1 | |
| SCHEMBL5746369 | 0.73 | KDR (0.48) | KDRPIM1ROCK1CLK4ROCK2 | |
| SCHEMBL2732653 | 0.72 | KDR (0.51) | KDRPIM1ROCK1CLK4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633710-A1 | ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS | Abbott Laboratories (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108672-A1 | ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-16 | — | — | WO | disclosed |