Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 6/20 | 0.68 |
| ▸ | CDK2 | P24941 | 6/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.65 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.65 |
| ▸ | CDK4 | P11802 | 7/20 | 0.64 |
| ▸ | CCND1 | P24385 | 7/20 | 0.64 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.64 |
| ▸ | CDK9 | P50750 | 5/20 | 0.64 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.64 |
| ▸ | CDK11A | Q9UQ88 | 5/20 | 0.64 |
| ▸ | LTK | P29376 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CDK7 | P50613 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.54 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744612 | 0.89 | CCNA2 (0.70) | CCNA2CDK2CDK5CDK5R1CDK4 | |
| SCHEMBL5743992 | 0.86 | CCNA2 (0.68) | CCNA2CDK2CDK5CDK5R1CDK4 | |
| SCHEMBL5742993 | 0.86 | CDK4 (0.80) | CCNA2CDK2CDK5CDK5R1CDK4 | |
| SCHEMBL5743612 | 0.85 | CDK4 (0.68) | CCNA2CDK2CDK5CDK5R1CDK4 | |
| SCHEMBL5741598 | 0.85 | CCNA2 (0.64) | CCNA2CDK2CDK5CDK5R1CDK4 | |
| SCHEMBL5745243 | 0.85 | MEN1 (0.59) | CCNA2CDK2CDK5CDK5R1CDK4 | |
| SCHEMBL5741273 | 0.84 | CCNA2 (0.62) | CCNA2CDK2CDK5CDK5R1CDK4 | |
| SCHEMBL5742426 | 0.84 | CCNA2 (0.62) | CCNA2CDK2CDK5CDK5R1CDK4 | |
| SCHEMBL4333315 | 0.83 | CCNA2 (0.64) | CCNA2CDK2CDK5CDK5R1CDK4 | |
| SCHEMBL5743038 | 0.83 | CDK4 (0.68) | CCNA2CDK2CDK5CDK5R1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358169-B1 | DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE | HOFFMANN LA ROCHE (CH) | 2006-01-11 | — | — | EP | claimed |