Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.59 |
| ▸ | TUBB | P07437 | 1/20 | 0.59 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.59 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.59 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.59 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.59 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.59 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.59 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.59 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.59 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 9/20 | 0.59 |
| ▸ | CCND1 | P24385 | 9/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.58 |
| ▸ | CDK9 | P50750 | 7/20 | 0.58 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.58 |
| ▸ | CDK11A | Q9UQ88 | 6/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744237 | 0.91 | MEN1 (0.60) | MEN1KMT2ATUBB8BTUBB4ATUBB | |
| SCHEMBL5741675 | 0.91 | CDK4 (0.68) | MEN1KMT2ATUBB8BTUBB4ATUBB | |
| SCHEMBL5743586 | 0.89 | CDK4 (0.75) | MEN1KMT2ATUBB8BTUBB4ATUBB | |
| SCHEMBL5741539 | 0.88 | TUBB8B (0.61) | MEN1KMT2ATUBB8BTUBB4ATUBB | |
| SCHEMBL5743138 | 0.86 | TUBB8B (0.56) | MEN1KMT2ATUBB8BTUBB4ATUBB | |
| SCHEMBL5742566 | 0.86 | CDK4 (0.56) | MEN1KMT2ATUBB8BTUBB4ATUBB | |
| SCHEMBL4338119 | 0.85 | TUBB8B (0.57) | MEN1KMT2ATUBB8BTUBB4ATUBB | |
| SCHEMBL14508118 | 0.85 | TUBB8B (0.57) | MEN1KMT2ATUBB8BTUBB4ATUBB | |
| SCHEMBL4340278 | 0.85 | TUBB8B (0.56) | MEN1KMT2ATUBB8BTUBB4ATUBB | |
| SCHEMBL5745698 | 0.85 | CCNA2 (0.68) | CDK4CCND1CCNT1CDK9CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358169-B1 | DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE | HOFFMANN LA ROCHE (CH) | 2006-01-11 | — | — | EP | claimed |