Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746120 | 0.98 | HRH3 (0.54) | HRH3KDM4ESMN1; SMN2LTA4HTDP1 | |
| SCHEMBL5745867 | 0.90 | ALDH1A1 (0.50) | HRH3KDM4ESMN1; SMN2ALDH1A1HTT | |
| SCHEMBL5749058 | 0.89 | ALDH1A1 (0.51) | HRH3KDM4EALDH1A1HTTL3MBTL1 | |
| SCHEMBL5747294 | 0.87 | ALDH1A1 (0.47) | HRH3KDM4ESMN1; SMN2ALDH1A1HTT | |
| SCHEMBL28956550 | 0.71 | CHRNB4 (0.48) | — | |
| SCHEMBL5749933 | 0.71 | HTR2A (0.48) | KDM4ELTA4HTDP1TSHRHTR3E | |
| SCHEMBL27418159 | 0.71 | RET (0.41) | HRH3TSHRALDH1A1 | |
| SCHEMBL5746581 | 0.70 | HRH3 (0.61) | HRH3KDM4ESMN1; SMN2TDP1TSHR | |
| SCHEMBL11669945 | 0.70 | FLT3 (0.44) | HRH3KDM4ESMN1; SMN2HTR3EHTR3B | |
| SCHEMBL28397007 | 0.69 | HTR2A (0.47) | HRH3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |